Methylenetetrahydrofolate reductase polymorphism, diet, and breast cancer in Korean women
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چکیده
منابع مشابه
Methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk in Moroccan women.
BACKGROUND Methylenetetrahydrofolate (MTHFR) enzyme plays an important role in folate metabolism which is involved in DNA methylation, repair, and synthesis. OBJECTIVE We investigated if the MTHFR C677T polymorphism modulates the risk of developing breast cancer in Moroccan women. METHODS Genotyping was performed by PCR-RFLP method on a sample of 96 patients with breast cancer and 117 contr...
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Homocysteine may play a causal role in cognitive decline. The authors analyzed the 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T genotype, a correlate of plasma homocysteine levels, among 6,653 participants in the Study of Osteoporotic Fractures, a community-based, prospective cohort study of older women in four US states. During the years 1986-1998, the authors assessed whether the di...
متن کاملFolate intake, methylenetetrahydrofolate reductase polymorphisms, and breast cancer risk in women from the Malmö Diet and Cancer cohort.
BACKGROUND Single nucleotide polymorphisms (SNP) of the folate-metabolizing enzyme methylenetetrahydrofolate reductase (MTHFR) may modify associations between folate intake and breast cancer. We examined if the association between tertiles of dietary folate equivalents (DFE) and breast cancer was different in subgroups according to genotypes of the MTHFR 677 C>T (rs1801133) and 1298A>C (rs18011...
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Folate derivatives are important in experimental colorectal carcinogenesis; low folate intake, particularly with substantial alcohol intake, is associated with increased risk. The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate, required for purine and thymidine syntheses, to 5-methyltetrahydrofolate, the primary circulatory for...
متن کاملMethylenetetrahydrofolate reductase, diet, and risk of colon cancer.
Individuals with different forms of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, carriers of the C677T mutation versus wild type, show differences in enzyme levels; these differences have been hypothesized to be related to DNA methylation and, perhaps, to the nucleotide pool size. Using data from an incident case-control study, we evaluated the combined effect of dietary intake of...
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ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2004
ISSN: 2092-6413
DOI: 10.1038/emm.2004.17